| ncRNA name | PARP-1 siRNA |
| ncRNA Category | siRNA |
| Disease name | cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | human lens epithelial cell line FHL124 |
| Methods | siRNA transfection, immunocytochemistry, Western blot, Alkaline comet assay |
| Expression pattern | associated |
| Functional description | PARP-1 inhibition rendered FHL124 cells more susceptible to H2O2-induced DNA strand breaks. Interestingly, reduction of PARP-1 activity significantly inhibited H2O2-induced cell death relative to control cells. Inhibition of PARP-1 in whole human lenses resulted in a reduced level of lens opacity and cell death following exposure to H2O2 relative to matched pair controls. |
| PubMed ID | 26990173 |
| Year | 2016 |
| Title | PARP-1 inhibition influences the oxidative stress response of the human lens. |
| Drug-related ncRNA | NO |
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